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Magou-V:Luo Han Guo Extract of 40% Mogroside V
Magou-VTM A natural, health sweet agent
 

Introduction of Luo Han Guo Extract
Luo Han Guo (Siraitia grosvenorii, or Momordica grosvenorii), that is mangosteen of cucurbitaceous family, the ripe fruit of a kind of perennial grass liana. There have been thousands of years that Chinese have known to soak the Luo Han Guo in water as a drink. Traditional of Chinese medicine as well applies it to cure disease, such as high blood pressure, pulmonary tuberculosis, asthma, gastritis, whooping cough, acute & chronic tracheitis and acute & chronic tonsillitis, etc. It is proved by recent researches that mogrosides is the main effective medical components. Luo Han Guo fruit and its extract are dual-use in therapeutic and health products. At present, Luo Han Guo is allowed use as a food additive in these countries: Japan, Korea, Thailand, Singapore, British, and China, etc.
 
Main Components of Mogrosides
Mogrosides, the mixture of cucurbitane glycoside, which have the common mogrol, are comprised with 11 kinds  of cucurbitane glycoside which are the Mogroside III, Mogrosied IV, Mogroside V, Mogroside IIE , Mogorside IIIE , Mogrosied A, Neomogroside, Siamenside I, and
11- Oxo- Mogroside V.
Mogroside IV is a component with no sweet taste. Mogroside A, Mogroside II, and Neomogroside are bitterness substance. In all cucurbitane glycoside, Siamenside I is the sweetest component, whose sweetness is approximate 563 times of sucrose. But its content in the fruit is very low. The content and sweet degree both high in all the mogrosides is Mogroside V, the sweet degree of which is approximate 256-344 times.
 
Mogrosides'  Biological Activity:
Mogrosides, the main active component of Luo Han Guo, whose biological activity and functional mechanism can be referred as as followings:
1.   In 1999, Chinese researchers Wang Ting and his group tested on the biological activity of 
      mogrosides by mice. Then they discovered that mogrosides is help to expectorant, antitussive 
      and calming asthma as well.
2.   In 2002, Japanese scientists Takao Konoshima and Midori Takasaki, and in 2003 Midori 
      Takasaki, they together discovered that Mogroside V and 11-Oxo-Mogroside V are both a strong 
       kind of chemical interdiction reagent through the in vivo and in vitro study . They stop and put a 
      curb on the activation of EBV-EA and the progress of the second phrase of cancerization of 
       mice's skin remarkable.
3.   In 2004, according to Maria Alejandra HOSSEN and his partners' researches, they discovered 
       the mixtures of mogrosides can stop the tickle caused by histamine medicine in mice's noses 
       effectively.
4.   In 2002, Eiichiro Takeo and his group proved that the extraction of Luo Han Guo can effectively 
      restrain the oxidation of low-density lipoprotein. So effectively dose 11-Oxo-mogroside V, whose 
      ability of oxidation depends on the degree of dosage, that is when dosage is less than 50uM, 
     11-Oxo-Mogroside V will not display its capacity of anti-oxidation. In addition, 11-Oxo-Mogroside V 
      also shows a certain ability of anti-oxidation to free-radical, but it is weaker than VE.
5.   In 2005, according to the researches of Yasushia Suzuki and his partners, extraction of Luo Han 
      Guo could restrain the rise of the density of blood-sugar of mice which had eaten maltose 
      effectively, while extraction of Luo Han Guo couldn't restrain that rise on the mice which had 
      eaten glucose.
It clearly puts out the special function of Luo Han Guo, that is, to lower density of mice's blood sugar by restraining activity of maltase in small intestines and decreasing absorption of maltose. In case it also works for human body, Mogrosides is hoped to be used for treatment Tyep II diabetes.
 
Advantage of Mogrosides:
1.   High sweet degree. Approximate 300 times of sucrose.
2.   Low calories. In an equal degree of sweet, Mogrosides' calorie is only 2% of that of sucrose's.
3.   Fine light color and fine water soluble. Mogrosides is a kind of yellowish powder and easily 
        soluble in water.
4.   Fine stability. It has excellent heat stability and wouldn't be spoiled even in 100℃ neutral water, 
       or in 120℃ air for hours. In addition, it can be maintained under PH value 2.0~10.0 for two 
       years without quality affected.
5.   Safe and dependable. Experimentations shows its LD50 value more than 100g/kg; and no side 
       effects found during thousands years using by Chinese people.
 
Examples in Practical Application of Mogrosides in Food Industry:
Mogrosides can partially or wholly replace sucrose in food industry. For example, add 0.012% mogrosides into dextrin can make soft sweets without adding sugar. When substitute mogrosides for sucrose in biscuits production, the texture and taste will be very nice. When making pickles, to add 0.005% Mogrosides to the solution can reduce costs of salt, while the pickles tastes more crisp and fresh.
 
Mogrosides (Luo Han Guo Extract) can be blended with some other herbal extract (Green Tea, Kuduz, etc) to make into instant tea bag, beside works as sweet properties, Luo Han Guo extract will also give benefit like thirst-quenching, diuretie, refreshing, lowering blood-pressure, promoting gastrointestinal function etc... To add Mogrosides(Luo Han Guo) into dairy products will also be a idea to create a new product. There is already Japan companies make Luo Han Guo extract into a Sugar-Substitute for coffee and tea. Anyway, Luo Han Guo extract is used in more and more in food industry with its natural benefit.
 
 
About Magou-VTM
 
1.    What is Magou-VTM?
Magou-VTM is the brand name of Luo Han Guo extract manufactured by Hill Pharmaceutical Co., Ltd., which is manufactured with our know-how technical through strict quality control system. It will meet cGMP and Kosher requirement. Magou-VTM will conform to a serial of high quality standard including color, solubility, tastes and standardized by 40% Mogroside V. Below is the Specification Sheet of Magou-VTM:
 

 

Product Name
:
Luo Han Guo Extract Powder
Botanical Name
:
Siraitia grosvenorii
(Syn. Momordica grosvenori)
Plant Part Used
:
Ripe fruit
Appearance
:
Off-white powder with high sweet taste
Identification Method
:
TLC
Mogroside V
:
NLT 40% by HPLC
Particular Size
:
NLT 95% pass 80 mesh screen
Solubility
:
Fine soluble
Solvent Used
 
Purified water
Carrier Used
:
None
Method of drying
:
Spray drying
Ash
:
NMT 5.0%
Moisture
:
NMT 5.0%
Heavy Metal
:
NMT 20ppm
Total Bacteria
:
NMT 1000/gram
Mold and Yeast
:
NMT 100/gram
Enterobacteria
:
NMT 100/gram
Colifroms
:
Negative/gram
Salmonella
:
Negative/10gram
Packing
:
25kg per drum, inside double plies vinyl pack
Storage
:
To be stored in cool and dry place
Re-Test Date
:
24 months after manufacture
Origin
:
China
 
2.    Magou-VTM  is standardized by 40% Mogroside V, while some other brands Luo Han Guo extract are labeled as 80% Mogrosides, what's the difference between them?
80% Mogrosides will contain all components which have same mogrol, among them there are some non-sweet components like Mogroside IV, and also bitter components like Mogroside A, Mogrosides II and Neomogroside. Since the main purpose of Magou-VTM will be used as sweetener, then the only meaningful way to control the quality will be to calculate the potency of the real sweet component. Mogroside V is one of the most sweet constitute in Luo Han Guo (another most sweet constitute is Siamenside I, but it is very few in Luo Han Guo, and not realistic in economic to extract it as a sweetener), therefore we standardize our product by this component. We have ever collect from market several brands Luo Han Guo extract which all claimed as 80% mogrosides, but their sweet potency is quite different, and the contents of Mogroside V in them differed from 17.6% to 34.4%. Therefore we prefer to control our product only by Mogroside V through a HPLC method, which is more accuracy to represent the true quality of the product. 


 
           HPLC figure of standard reference Mogroside V                                HPLC figure of Magou-VTM
 
3.   Why Magou-VTM should be the priority choice when food/drink manufacturers consider using Luo Han Guo product as sweet agent?
As sweetener, the ideal taste would be like refined white sugar, means no other miscellaneous flavors except sweetness. Most people may not expect his Latte becomes a cup of licorice liquid or something alike right after he added sweetener. So, it is very important to minimize the characteristic taste of Luo Han Guo, and only remain its sweetness. In this point, we dare to say Magou-VTM is the most successful product with its pure, neutral and long-lasting sweetness. Though it doesn't completely eliminate each flavor trace of Luo Han Guo, it already consumedly exceeds other brands. All of these should be given credits to our special manufacturing technologies and strict management of quality.
 
4.   Why we set Mogroside V 40% as the quality standard, not 60% or 20%?
It is proved by our researches that an extract contains 20% Magroside V will keep too many characteristic Luo Han Guo taste, therefore this grade should not be suitable as sweetener. On another hand, when the content of Mogroside V has been improved to 60% in the extract, its cost will be double of 40% grade when receive same sweet degree, but its taste in purity side seems has not been conspicuously meliorated. Consequently, we standardized our Magou-VTM by 40% Mogroside V to enable our customers will use the best products at relative lowest costs.
 


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